498579-20-7

Upstream product

• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 160238-46-0 (2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal 
• 160238-45-9 (2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol 
• 498579-17-2 (E)-(S)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-enoic acid ethyl ester 

Downstream Products

• 498578-86-2 (E)-(S)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-enal 
• 498579-25-2 (2E,8E)-(4S,5R,6S,7R,10S)-7-(tert-Butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-5-triethylsilanyloxy-undeca-2,8-dienoic acid methyl ester 
• 498579-06-9 (2E,8E)-(4S,5R,6S,7R,10S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-undeca-2,8-dienoic acid methyl ester 
• 498579-22-9 (2E,8E)-(4R,5R,6S,7R,10S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-undeca-2,8-dienoic acid methyl ester 
• 498579-03-6 (2E,8E)-(4S,5R,6S,7R,10S)-7-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-undeca-2,8-dienoic acid methyl ester 
• 498578-88-4 (R)-4-Benzyl-3-[(E)-(2R,3R,6S)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-hept-4-enoyl]-oxazolidin-2-one 
• 498578-91-9 (E)-(2R,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-hept-4-enoic acid methoxy-methyl-amide 
• 498578-94-2 (E)-(2R,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-hept-4-enal 

Relevant academic research and scientific papers

Synthesis of the C1-C11 segment of tedanolide via vinylogous Mukaiyama aldol reaction

The successful construction of complex natural products depends to a large extent on how efficiently key intermediates can be generated. Here we report our efforts towards the first total synthesis of tedanolide (1), employing Evans' aldol methodology in combination with a vinylogous Mukaiyama aldol reaction (VMAR) and Sharpless' asymmetric dihydroxylation. This protocol allows for rapid access to its numerous chiral centers.