498579-17-2

Upstream product

• 80673-78-5 ethyl (2-dimethoxyphosphinyl)-2-propanoate 
• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 160238-45-9 (2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol 
• 160238-46-0 (2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 

Downstream Products

• 498579-20-7 (E)-(S)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-en-1-ol 
• 498579-25-2 (2E,8E)-(4S,5R,6S,7R,10S)-7-(tert-Butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-5-triethylsilanyloxy-undeca-2,8-dienoic acid methyl ester 
• 498579-06-9 (2E,8E)-(4S,5R,6S,7R,10S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-undeca-2,8-dienoic acid methyl ester 
• 498579-22-9 (2E,8E)-(4R,5R,6S,7R,10S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-undeca-2,8-dienoic acid methyl ester 
• 498579-03-6 (2E,8E)-(4S,5R,6S,7R,10S)-7-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-11-(4-methoxy-benzyloxy)-4,6,8,10-tetramethyl-undeca-2,8-dienoic acid methyl ester 
• 498578-88-4 (R)-4-Benzyl-3-[(E)-(2R,3R,6S)-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-hept-4-enoyl]-oxazolidin-2-one 
• 498578-91-9 (E)-(2R,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-hept-4-enoic acid methoxy-methyl-amide 
• 498578-94-2 (E)-(2R,3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,4,6-trimethyl-hept-4-enal 
• 498578-86-2 (E)-(S)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-enal 
• 117582-92-0 iejimalide B 
• 947412-61-5 C₅₃H₇₈N₂O₇Si 

Relevant academic research and scientific papers

IEJIMALID ANALOGA AND USES THEREOF

The invention relates to Iejimalides having the following formula (I) in which a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p are simple or double bonds, the continuous lines representing at least one simple bond, the dotted lines representing a possible

Total synthesis of iejimalide A-D and assessment of the remarkable actin-depolymerizing capacity of these polyene macrolides

A concise and convergent total synthesis of the highly cytotoxic marine natural products iejimalide A-D (1-4) is reported, which relies on an effective ring-closing metathesis (RCM) reaction of a cyclization precursor containing no less than 10 double bon

Synthesis of the C1-C11 segment of tedanolide via vinylogous Mukaiyama aldol reaction

The successful construction of complex natural products depends to a large extent on how efficiently key intermediates can be generated. Here we report our efforts towards the first total synthesis of tedanolide (1), employing Evans' aldol methodology in combination with a vinylogous Mukaiyama aldol reaction (VMAR) and Sharpless' asymmetric dihydroxylation. This protocol allows for rapid access to its numerous chiral centers.