4990-82-3

Usage

InChI:InChI=1/C7H12Cl2O4/c1-12-7-6(11)5(10)4(9)3(2-8)13-7/h3-7,10-11H,2H2,1H3/t3-,4+,5+,6-,7+/m1/s1

Upstream product

• 91470-17-6 methyl-(4,6-dichloro-O²,O³-sulfonyl-4,6-dideoxy-α-D-galactopyranoside) 
• 97-30-3 methyl-alpha-D-glucopyranoside 

Downstream Products

• 86040-02-0 3-O-Benzoyl-2,4,6-tridesoxy-5-O-tetrahydropyranyl-L-threo-hexose-trimethylendithioacetal 
• 86040-02-0 3-O-Benzoyl-2,4,6-tridesoxy-5-O-tetrahydropyranyl-D-erythro-hexose-trimethylendithioacetal 
• 20585-18-6 methyl 4,6-dideoxy-α-D-glucopyranoside 
• 152755-02-7 (3S,5S,6R)-6-(1',3'-dithian-2'-yl)-5,6-(isopropylidenedioxy)-1-(phenylsulfonyl)hexan-3-ol 
• 152755-21-0 (4S,6S)-4-(1',3'-dithian-2'-ylmethyl)-2,2-dimethyl-6-<2-(phenylsulfonyl)ethyl>-1,3-dioxane 
• 152755-05-0 (2S,4S)-1-(1',3'-dithian-2'-yl)-6-phenylsulfonylhexane-2,4-diol 
• 152755-06-1 (2S,4S)-1-(1',3'-dithian-2'-yl)-5-(p-methoxybenzyloxy)pentane-2,4-diol 
• 114047-94-8 (4S,6S)-4-<2'-<(3''S,4''R)-4''-(tert-butyldimethylsiloxy)-3'',5''-dimethylhexyl>-1',3'-dithian-2'-ylmethyl>-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxane 
• 114057-13-5 (4S,6S)-4-(1',3'-dithian-2'-ylmethyl)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl-1,3-dioxane 
• 114047-93-7 (2S,4S)-1-(1',3'-dithian-2'-ylidene)-5-(p-methoxybenzyloxy)pentane-2,4-diol 
• 69734-25-4 methyl 4,6-dideoxy-2-O-p-tosyl-α-D-xylo-hexopyranoside 
• 86040-00-8 (S)-1-((4S,5R)-5-(1,3-dithian-2-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)propan-2-yl benzoate 
• 863444-49-9 6-O-benzoyl-1,1-dibromo-5,7-dideoxy-3,4-O-isopropyliden-L-arabino-hept-1-ene 

Relevant academic research and scientific papers

MACROLIDES AND METHODS OF THEIR PREPARATION AND USE

Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

Concise syntheses of d-desosamine, 2-thiopyrimidinyl desosamine donors, and methyl desosaminide analogues from d-glucose

A concise synthesis of d-desosamine has been accomplished in five steps and in 15% overall yield from methyl α-d-glucopyranoside. Desosamine was then transformed into two known 2-thiopyrimidinyl donors (Woodward and Tatsuta donors), each in two steps. Finally, analogues of methyl desosaminide at the C-3 position were prepared (3-pyrrolidino, 3-piperidino, 3-morpholino) from a common 2,3-anhydrosugar intermediate.

New approaches towards the synthesis of the side-chain of mycolactones A and B

New approaches towards the synthesis of the C1′-C16′ side-chain of mycolactones A and B from Mycobacterium ulcerans are reported. Chiral building block 4 (Fig. 2) with the correct stereochemistry was obtained starting from naturally occurring monosacchari

Asymmetric Synthesis of the Spiroacetal Fragment of Milbemycin E

Spiro-acetals (17) and (21) have been synthesized from methyl α-D-glucopyranoside (11), via the 6-chloro-4,6-dideoxygalactopyranoside (10), the epoxy-dithiane (8), and the open-chain dithianes (16) and (20).