499200-30-5Relevant academic research and scientific papers
Steric tuning of silylacetylenes and chiral phosphine ligands for rhodium-catalyzed asymmetric conjugate alkynylation of enones
Nishimura, Takahiro,Guo, Xun-Xiang,Uchiyama, Nanase,Katoh, Taisuke,Hayashi, Tamio
, p. 1576 - 1577 (2008/09/17)
Rhodium-catalyzed asymmetric conjugate alkynylation of α,β-unsaturated ketones giving β-alkynylketones took place in high yields with high enantioselectivity. The reaction was realized by use of (triisopropylsilyl)acetylene combined with (R)-DTBM-segphos as a chiral phosphine ligand, where the sterically bulky substituents on the silicon and phosphorus atoms suppress the alkyne dimerization. Copyright
