499200-32-7Relevant academic research and scientific papers
Steric tuning of silylacetylenes and chiral phosphine ligands for rhodium-catalyzed asymmetric conjugate alkynylation of enones
Nishimura, Takahiro,Guo, Xun-Xiang,Uchiyama, Nanase,Katoh, Taisuke,Hayashi, Tamio
, p. 1576 - 1577 (2008/09/17)
Rhodium-catalyzed asymmetric conjugate alkynylation of α,β-unsaturated ketones giving β-alkynylketones took place in high yields with high enantioselectivity. The reaction was realized by use of (triisopropylsilyl)acetylene combined with (R)-DTBM-segphos as a chiral phosphine ligand, where the sterically bulky substituents on the silicon and phosphorus atoms suppress the alkyne dimerization. Copyright
Rhodium-catalyzed asymmetric rearrangement of alkynyl alkenyl carbinols: Synthetic equivalent to asymmetric conjugate alkynylation of enones
Nishimura, Takahiro,Katoh, Taisuke,Takatsu, Keishi,Shintani, Ryo,Hayashi, Tamio
, p. 14158 - 14159 (2008/09/18)
Asymmetric 1,3-rearrangement of an alkynyl group of alkynyl alkenyl carbinols giving β-alkynylketones took place in high yields with high enantioselectivity in the presence of a hydroxyrhodium/(R)-binap catalyst. The present method including a key β-alkynyl elimination step in the catalytic cycle is synthetically equivalent to the asymmetric conjugate addition of terminal alkynes to β-substituted enones. Copyright
