499237-38-6

Upstream product

• 39192-51-3 1-(3,5-dimethoxyphenyl)heptan-1-one 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 111-66-0 oct-1-ene 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 

Downstream Products

• 499237-39-7 1-(2,2-dichloro-1-hexyl-cyclopropyl)-3,5-dimethoxy-benzene 
• 499237-44-4 1-(2,2-dibromo-1-hexyl-cyclopropyl)-3,5-dimethoxy-benzene 
• 499237-41-1 5-(2,2-dibromo-1-hexyl-cyclopropyl)-benzene-1,3-diol 
• 499237-40-0 5-(2,2-dichloro-1-hexyl-cyclopropyl)-benzene-1,3-diol 

Relevant academic research and scientific papers

Regioselective Heck reaction of aliphatic olefins and aryl halides

A regioselective Heck reaction of aliphatic olefins and aryl bromides is realized at internal carbons of olefins. Methanol solvent promoted halide ionization from neutral arylpalladium halide complexes via hydrogen bonding, so as to create cationic aryl-Pd species for regioselective olefin insertion.

Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols

1′,1′-Cyclopropyl side chain substituents enhance the affinities of Δ8-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1′,1′-cyclopropyl analogues are described.