4995-54-4Relevant academic research and scientific papers
Synthesis and Conformational Studies on some Nitro- and Aminophthalideisoquinoline Derivatives
Marton, J.,Hosztafi, S.,Koever, K. E.
, p. 291 - 298 (1993)
Nitro- and Aminophthalideisoquinolines were synthesized with a new efficient method.The molecular conformation of these derivatives was studied by 1H NMR methods.On the basis of these studies tritoqualine was to be found the erythro racemate. Keywords: Aminophthalideisoquinolines; Conformational analysis; Nitrophthalideisoquinolines; Reduction with ammonium formate.
Process for preparation of phthalide derivatives
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, (2008/06/13)
Disclosed herein is a process for preparing phthalide derivatives represented by the general formula (IV): STR1 wherein R1 to R7 are herein defined, comprising (i) reacting a nitrophthalide of the general formula (I) defined herein with an isoquinoline of the general formula (II) defined herein, and (ii) reducing the resultant phthalideisoquinoline of the general formula (III) defined herein. The process is characterized in (A) that the reaction defined in (i) is carried out in methanol, and/or (B) that the nitrophthalide of the general formula (I) is a nitrophthalide obtained by a reaction of a phthalide of the general formula (V) defined herein with copper nitrate or zinc nitrate.
