4997-20-0Relevant academic research and scientific papers
Structure Investigations on Products from the Reaction of Organocopper, Organolithium and Organomagnesium Reagents with 2(1H)-Pyrimidinones
Rise, Frode,Romming, Christian,Undheim, Kjell
, p. 459 - 468 (2007/10/02)
Alkyl- and arylcuprates and alkyl- and aryllithium and -magnesium reagents form 3,4- or/and 3,6-adducts with 1-benzyl-2(1H)pyrimidinones.The effect of 5-halo substituents on the reactivity and regioselectivity is reported.Structure analyses were made by NMR spectroscopy.Dehydrogenation gives the conjugated, substituted pyrimidinines.X-Ray crystallographic data for 1-benzyl-5-chloro-4-phenyl-2(1H)-pyrimidinone and its regioisomer 1-benzyl-5-chloro-6-phenyl-2(1H)-pyrimidinone are discussed.
