499773-70-5Relevant academic research and scientific papers
Non-cryogenic metalation of aryl bromides bearing proton donating groups: Formation of a stable magnesio-intermediate
Kato, Shinji,Nonoyama, Nobuaki,Tomimoto, Koji,Mase, Toshiaki
, p. 7315 - 7317 (2002)
Bromine-metal exchange of o-bromobenzoic acid (1) with Bu2Mg followed by n-BuLi was successfully carried out at non-cryogenic temperature (>-20°C), and gave a stabilized metal species which smoothly reacted with several electrophiles. This methodology expanded to several other bromides bearing proton donating groups (PDGs).
METHOD OF SUBSTITUENT INTRODUCTION THROUGH HALOGEN-METAL EXCHANGE REACTION
-
Page/Page column 19, (2010/02/10)
A method of exchanging a halogen atom of a halide, which has a group containing an acidic proton and in which one or more halogen atom(s) is/are substituted on a carbon atom of the carbon-carbon double bond, with a metal atom by halogen-metal-exchange reaction and introducing an electrophilic reagent into the carbon atom to which the metal atom is attached. The above method is an industrially excellent method of introducing a substituent by halogen-metal exchange reaction.
