499783-16-3Relevant academic research and scientific papers
Pyridazines. Part XXIX: Synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions
Sotelo, Eddy,Fraiz, Nuria,Yáez, Matilde,Terrades, Vicente,Laguna, Reyes,Cano, Ernesto,Ravia, Enrique
, p. 2873 - 2882 (2007/10/03)
A series of 6-phenyl-3(2H)-pyridazinones with a diverse range of substituents in the 5-position have been prepared and evaluated in the search for new antiplatelet agents. A significant dependence of the substituent on the inhibitory effect has been observed. The pharmacological study of these compounds confirms that modification of the chemical group at position 5 of the 6-phenyl-3(2H)-pyridazinone system influences both variations in the antiplatelet activity and the mechanism of action.
