499784-07-5

Upstream product

• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 499784-01-9 3-(2-methoxyphenyl)-4-(4-methylthiophenyl)-2(5H)furanone 
• 499783-97-0 4-methylthiophenacyl 2-methoxyphenylacetate 
• 100-68-5 methyl-phenyl-thioether 
• 1778-09-2 4-(Methylthio)acetophenone 
• 75-36-5 acetyl chloride 
• 499784-04-2 3-(2-hydroxy-phenyl)-4-(4-methylsulfanyl-phenyl)-5H-furan-2-one 

Relevant academic research and scientific papers

Isomeric acetoxy analogues of rofecoxib: A novel class of highly potent and selective cyclooxygenase-2 inhibitors

A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.