500018-96-2

Upstream product

• 124685-23-0 1-[(3'R,4'R)-2',5',6'-trideoxy-6'-(diethoxyphosphinyl)-β-hexofuranosyl]thymine 
• 65-85-0 benzoic acid 
• 683-08-9 Diethyl methylphosphonate 
• 682-30-4 Diethyl vinylphosphonate 
• 7481-90-5 3',4'-anhydrothymidine 

Downstream Products

• 500018-98-4 2'-deoxy-O^P-ethyl-5'-O-(4,4'-dimethoxytrityl)thymidylylmethylene-(3'->5')-3'-O-benzoyl-2',5'-dideoxythymidine 
• 500018-99-5 2'-Deoxy-O^P-ethyl-5'-O-(4,4'-dimethoxytrityl)thymidylylmethylene-(3'->5')-2',5'-dideoxythymidine 
• 500018-97-3 1-[(3'S,4'R)-3'-O-benzoyl-2',5',6'-trideoxy-6'-(ethoxyhydroxyphosphinyl)-β-hexofuranosyl]thymine 

Relevant academic research and scientific papers

Photoredox-Catalyzed Deformylative 1,4-Addition of 2′-Deoxy-5′- O-phthalimidonucleosides for Synthesis of 5′-Carba Analogs of Nucleoside 5′-Phosphates

A concise approach for the synthesis of the 5′-carba analogs of nucleoside 5′-phosphates from 2′-deoxy-5′-O-phthalimidonucleosides by a visible-light-mediated deformylative 1,4-addition was developed. This method enabled rapid and facile generation of 4′-carbon radicals of nucleosides. Moreover, this synthetic strategy was applicable to the 5′-carba analogs of nucleoside 5′-phosphates as well as other 5′-carba nucleosides bearing methoxycarbonyl, cyano, and N-methylsulfamoyl groups.

From phosphate to bis(methylene) sulfone: Non-ionic backbone linkers in DNA

Chimeric DNA molecules containing four different linking groups, the natural phosphate, 5′-methylenephosphonate, bis(methylene)phosphinate, and bis(methylene) sulfone (see Fig. 1), were directly compared for their ability to form duplexes with complementa