500022-69-5Relevant academic research and scientific papers
Tailoring buchwald-type phosphines with pyrimidinium betaines as versatile aryl group surrogates
Nol-Duchesneau, Ludovik,Lugan, Nol,Lavigne, Guy,Labande, Agns,Csar, Vincent
, p. 5085 - 5088 (2014)
A derivatization of dialkylbiarylphosphines consisting in the formal replacement of their distal aryl group by a pyrimidinium betaine is reported. Two achiral representatives of this new class of Buchwald-type phosphines have been successfully synthesized through two strategies. The first one is based on a last stage introduction of the phosphino moiety, and the second one consists in a modular, one-pot, three-step procedure starting from an o-bromoaryl phosphine. The resulting phosphines have been coordinated onto gold(I) and palladium(II) centers and have been employed as supporting ligands in Pd-catalyzed Suzuki-Miyaura cross-coupling of aryl halide substrates.
