500108-46-3Relevant academic research and scientific papers
Enzymatic preparation of (3R)-cis-3-acetyloxy-4-(1,1-dimethylethyl)-2- azetidinone: A side-chain synthon for an orally active taxane
Patel, Ramesh N.,Howell, Jeffrey,Chidambaram, Rama,Benoit, Serge,Kant, Joydeep
, p. 3673 - 3677 (2003)
The chiral intermediate (3R)-cis-3-acetyloxy-4-(1,1-dimethylethyl)-2- azetidinone 2 was prepared for the semi-synthesis of the new taxane 5, an orally active anticancer compound. The enantioselective enzymatic hydrolysis of cis-3-acetyloxy-4-(1,1-dimethylethyl)-2-azetidinone 1 to the corresponding undesired (S)-alcohol 3 and unreacted desired 2 was carried out using immobilized lipase PS-30 or BMS lipase. Reaction yields of >48% and enantiomeric excesses of >99% were obtained for the desired 2. Acetoxy β-lactam 2 was converted to hydroxy β-lactam 4 for use in the semisynthesis of 5.
Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains
Anand, Naveen,Kapoor, Munish,Ahmad, Khursheed,Koul, Surrinder,Parshad, Rajinder,Manhas, Kuldip S.,Sharma, Rattan L.,Qazi, Ghulam N.,Taneja, Subhash C.
, p. 1059 - 1069 (2008/01/07)
The native strain of Arthrobacter sp. (MTCC 5125) bearing a lipase has been found to be the most effective in the kinetic resolution of racemic arylazetidinones for producing cis-(3R,4S)-3-acetoxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone, cis-(3R,4S)-3-
New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 5
Takeda, Yasuyuki,Uoto, Kouichi,Iwahana, Michio,Jimbo, Takeshi,Nagata, Motoko,Atsumi, Ryo,Ono, Chiho,Tanaka, Noriko,Terasawa, Hirofumi,Soga, Tsunehiko
, p. 3209 - 3215 (2007/10/03)
To improve the metabolic stability of 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogues. Most of the synthetic compounds maintained excellent antitum
