500131-94-2

Upstream product

• 150-19-6 O-methylresorcine 
• 500131-82-8 2-bromo-1-methoxy-3-[(methylthio)methoxy]benzene 
• 500131-83-9 (3R,5S,8aR)-5-[(2-bromo-3-methoxyphenoxy)methyl]-3-phenyl-hexahydro-5H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile 
• 500131-89-5 2-bromo-1-(chloromethoxy)-3-methoxybenzene 
• 146746-58-9 1-bromo-2-methoxy-6-(methoxymethoxy)benzene 
• 135999-16-5 2-Bromo-3-methoxyphennol 
• 57234-28-3 1-methoxy-3-(methoxymethoxy)benzene 
• 500131-84-0 (2R)-2-[(1S,12S)-5-methoxy-10-oxa-2,16-diazatetracyclo[10.3.1.0^3,12.0^4,9]hexadeca-2,4⁽⁹⁾,5,7-tetraen-16-yl]-2-phenyl-1-ethanol 

Downstream Products

• 500131-85-1 (3'S,4'R)-[(1R)-2-hydroxy-1-phenylethyl]-4'-hydroxy-5'-methoxy-3',4'-dihydrospiro[piperidine-2,3'(2'H)-benzopyran] 

Relevant academic research and scientific papers

Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy

Enantiomerically pure (3′R)- and (3′S)-3′,4′-dihydrospiro[piperidine-2,3′ (2′H)-benzopyran]s (R)-10 and (S)-10 were successfully synthesized according to the CN(R,S) methodology with the aim of serving as a pattern for the generation of related spirocyclic compounds. Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine (-)-2. One of them was selected and used for the preparation of amines (R)-17 and (S)-17 starting from (-)-2 and (+)-2, respectively. The enantiomeric purity of all final aminochroman derivatives was determinated by capillary electrophoresis using β-cyclodextrin as the chiral selector.