500148-57-2Relevant academic research and scientific papers
Mild and efficient synthesis of 1,2,4-triazolo[4,3-a][l,8] naphthyridines using FeCl3 in the solid state
Mogilaiah,Vidya,Swamy
experimental part, p. 599 - 601 (2009/12/09)
An efficient, rapid and mild method for the synthesis of 1,2,4- triazolo-[4,3-a][l,8]naphthyridines 4 by the oxidative cyclization of vanillin 3-aryl-l,8-naphthyridine-2-yl hydrazones 3 with FeCI3.6H2O in the solid state by grinding at room temperature has been described. The products are obtained in good yields with high purity.
Hypervalent iodine mediated synthesis of 1,2,4-triazolo [4,3-a] [1,8]naphthyridines
Mogilaiah,Srinivasa Chowdary
, p. 1894 - 1898 (2007/10/03)
2-Aminonicotinaldehyde 1 on condensation with p-chlorophenylacetonitrile 2 affords 2-amino-3-(p-chlorophenyl)-1,8-naphthyridine 3, which is converted into 2-hydrazino-3-(p-chlorophenyl)-1,8-naphthyridine 4 by the reaction with hydrazine hydrate and conc.
