5002-98-2

Basic information

• Product Name: (R)-2-((3-bromophenoxy)methyl)oxirane
• CAS NO: 5002-98-2
• Molecular Weight: 229.073
• Mol File: 5002-98-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-2-((3-bromophenoxy)methyl)oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-((3-bromophenoxy)methyl)oxirane(5002-98-2)
• EPA Substance Registry System: (R)-2-((3-bromophenoxy)methyl)oxirane(5002-98-2)

Safety Data

• Hazardous Substances Data: 5002-98-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(R)-2-((3-bromophenoxy)methyl)oxirane" is a stereoisomer of a compound that consists of an oxirane ring attached to a 3-bromophenoxy group and a methyl group. Oxirane, also known as epoxyethane, is a three-membered cyclic ether with a characteristic strained ring structure. The 3-bromophenoxy group is a phenyl group substituted with a bromine atom attached to the third carbon atom. (R)-2-((3-bromophenoxy)methyl)oxirane may have applications in organic synthesis, pharmaceuticals, or as a starting material for the production of other chemicals. It is important to handle and store this compound with caution due to its potential reactivity and toxicity.

Upstream product

• 591-20-8 3-Bromophenol 
• 123750-60-7 (2R)-glycidyl 4-nitrobenzenesulfonate 
• 67843-74-7 (S)-epichlorohydrin 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific community with in vivo-active tool compound EPZ015666 (GSK3235025) to probe the underlying pharmacology of this key enzyme. Herein, we report the design and optimization strategies employed on an initial hit compound with poor in vitro clearance to yield in vivo tool compound EPZ015666 and an additional potent in vitro tool molecule EPZ015866 (GSK3203591).

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described