123750-60-7Relevant articles and documents
Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues
Marquis, Robert W.,Lago, Amparo M.,Callahan, James F.,Rahman, Attiq,Dong, Xiaoyang,Stroup, George B.,Hoffman, Sandra,Gowen, Maxine,DelMar, Eric G.,Van Wagenen, Bradford C.,Logan, Sarah,Shimizu, Scott,Fox, John,Nemeth, Edward F.,Roethke, Theresa,Smith, Brian R.,Ward, Keith W.,Bhatnagar, Pradip
experimental part, p. 6599 - 6605 (2010/04/03)
When administered as a single agent to rats, the previously reported calcium receptor antagonist 3 elicited a sustained elevation of plasma PTH resulting in no increase in overall bone mineral density. The lack of a bone building effect for analogue 3 was
Arenesulfonate Derivatives of Homochiral Glycidol: Versatile Chiral Building Blocks for Organic Synthesis
Klunder, Janice M.,Onami, Tetsuo,Sharpless, K. Barry
, p. 1295 - 1304 (2007/10/02)
The preparation of a series of crystalline arenesulfonate derivatives of enantiomerically enriched glycidol is described.The enhancement of optical purity by recrystallization was particularly successful for two of these derivatives, glycidyl tosylate and glycidyl 3-nitrobenzenesulfonate, which were obtained in 97 percent ee and 99 percent ee, respectively.Very high regioselectivity was observed in the reactions of these compounds with a variety of nucleophiles, including aryl oxides, Et2AlCN, organometallic reagents, and BH3-NaBH4.The application of this methodology to the synthesis of homochiral β-adrenergic blocking agents and homochiral terminal epoxides is discussed.
