500214-48-2Relevant academic research and scientific papers
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity
Ruchelman, Alexander L.,Singh, Sudhir K.,Ray, Abhijit,Wu, Xiao Hua,Yang, Jin-Ming,Li, Tsai-Kun,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 2061 - 2073 (2007/10/03)
5H-Dibenzo[c,h]1,6-naphthyridine-6-ones can exhibit potent antitumor activity. The effect of varied substituents at the 5-position of 5H-8,9-dimethoxy-2,3-methylenedioxydibenzo[c,h]1,6-naphthyridine on relative cytotoxicity and topoisomerase I-targeting a
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.
Ruchelman, Alexander L,Singh, Sudhir K,Wu, Xiaohua,Ray, Abhijit,Yang, Jin-Ming,Li, Tsai-Kun,Liu, Angela,Liu, Leroy F,LaVoie, Edmond J
, p. 3333 - 3336 (2007/10/03)
Several 5,12-diazachrysen-6-ones and 5,6,11-triazachrysen-12-ones were synthesized with varied substituents at the 5- or 11-position, respectively. Each compound was evaluated for its potential to stabilize the cleavable complex formed with TOP1 and DNA.
