500224-61-3Relevant academic research and scientific papers
An alternative approach towards novel heterocycle-fused 1, 4-diazepin-2-ones by an aromatic amidation protocol
Correa, Arkaitz,Herrero, M. Teresa,Tellitu, Imanol,Domínguez, Esther,Moreno, Isabel,SanMartin, Raúl
, p. 7103 - 7110 (2007/10/03)
The synthesis of new 1,4-diazepin-2-one derivatives starting from glycine or alanine aminoacids is presented. The key cyclization step includes the PIFA mediated formation of N-acylnitrenium ions and their subsequent intramolecular trapping by an (hetero)aromatic ring. The so-promoted aromatic amidation process takes place without loss of enantiomeric purity when optically pure methoxyamide precursors are employed.
A novel and efficient iodine(III)-mediated access to 1,4-benzodiazepin-2-ones
Herrero, M.Teresa,Tellitu, Imanol,Domínguez, Esther,Moreno, Isabel,SanMartín, Raúl
, p. 8273 - 8275 (2007/10/03)
A novel access to 1,4-benzodiazepin-2-ones starting from glycine and alanine derivatives is described. The key cyclization step was performed by the action of phenyliodine(III)bis(trifluoroacetate) (PIFA) on the corresponding methoxyamide derivatives lead
