79821-71-9Relevant academic research and scientific papers
A novel and efficient iodine(III)-mediated access to 1,4-benzodiazepin-2-ones
Herrero, M.Teresa,Tellitu, Imanol,Domínguez, Esther,Moreno, Isabel,SanMartín, Raúl
, p. 8273 - 8275 (2002)
A novel access to 1,4-benzodiazepin-2-ones starting from glycine and alanine derivatives is described. The key cyclization step was performed by the action of phenyliodine(III)bis(trifluoroacetate) (PIFA) on the corresponding methoxyamide derivatives lead
An alternative approach towards novel heterocycle-fused 1, 4-diazepin-2-ones by an aromatic amidation protocol
Correa, Arkaitz,Herrero, M. Teresa,Tellitu, Imanol,Domínguez, Esther,Moreno, Isabel,SanMartin, Raúl
, p. 7103 - 7110 (2007/10/03)
The synthesis of new 1,4-diazepin-2-one derivatives starting from glycine or alanine aminoacids is presented. The key cyclization step includes the PIFA mediated formation of N-acylnitrenium ions and their subsequent intramolecular trapping by an (hetero)aromatic ring. The so-promoted aromatic amidation process takes place without loss of enantiomeric purity when optically pure methoxyamide precursors are employed.
