500228-07-9

Upstream product

• 500228-03-5 (+)-{4-{{3-{[(Benzyloxy)carbonyl]amino}propyl}{(2S)-3-[(4-benzyloxy)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoyl}amino}butyl}carbaminsaeure-benzylester 
• 74243-85-9 trans-2,3-bis(ethoxycarbonyl)oxirane 
• 89965-56-0 <3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 93061-20-2 (-)-(2R,3R)-trans-Oxiran-2,3-dicarbonsaeure-monoethylester 
• 500228-04-6 (+)-{{4-{(2S)-2-Amino-3-[4-(benzyloxy)phenyl]propanoyl}{3-{[(benzyloxy)carbonyl]amino}propyl}amino}butyl}carbonsaeure-benzylester 

Downstream Products

• 500228-08-0 (-)-(2R,3R)-3-{{(1S)-1-{{4-{[(Benzyloxy)carbonyl]amino}butyl}{3-{[(benzyloxy)carbonyl]amino}propyl}carbamoyl}-2-[4-(benzyloxy)phenyl]ethyl}carbamoyl}oxiran-2-carbonsaeure 

Relevant academic research and scientific papers

Configuration and enantioselective synthesis of the fungal metabolite WF14861

A short enantioselective synthesis of the cathepsine inhibitor WF14861 (1) from the funghi Colletotrichum sp. as well as of its diasteroisomer 21 is presented. Comparison of the NMR data of the final products and, in particular, of the [α]D values of the intermediates allowed the confirmation of the formerly proposed structure 1. In addition, the so far unknown absolute configuration of all three stereogenic centres of WF14861 could be established by this synthesis.