500293-65-2Relevant academic research and scientific papers
Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid
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Page/Page column 58; 65, (2015/12/04)
The invention provides a novel pharmaceutical composition comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base characterized in that the acid respectively base:drug compound ratio is at least 1:1 by weight.
Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains
Mordant, Celine,Schmitt, Benoit,Pasquier, Elisabeth,Demestre, Christophe,Queguiner, Laurence,Masungi, Chantal,Peeters, Anik,Smeulders, Liesbeth,Bettens, Eva,Hertogs, Kurt,Heeres, Jan,Lewi, Paul,Guillemont, Jerome
, p. 567 - 579 (2008/02/10)
Novel diarylpyrimidines (DAPY), which represent next generation of non-nucleoside reverse transcriptase inhibitors (NNRTIs), were synthesized and their activities against human immunodeficiency virus type I (HIV-1) assessed. Modulations at positions 2 and
