500316-80-3Relevant academic research and scientific papers
Synthesis of novel chiral ligands from amino acids by the Ugi reaction
Dyker, Gerald,Breitenstein, Klaus,Henkel, Gerald
, p. 1929 - 1936 (2002)
The Ugi multi-component reaction is employed for the efficient synthesis of chiral ligands starting from amino acids and aryl aldehydes bearing a Lewis-base functionality. Tests on the products as ligands for enantioselective transition metal catalysis gave promising results in the palladium-catalyzed allylic substitution with e.e. values up to 81%.
