500318-50-3Relevant articles and documents
Studies directed toward the total synthesis of pinnatoxin A: Synthesis of the 6,5,6-dispiroketal (BCD ring) system by double hemiketal formation/hetero-Michael addition strategy
Nakamura, Seiichi,Inagaki, Jun,Kudo, Masashi,Sugimoto, Tomohiro,Obara, Kohei,Nakajima, Makoto,Hashimoto, Shunichi
, p. 10353 - 10374 (2007/10/03)
An efficient, highly stereoselective synthesis of the C10-C26 portion of pinnatoxin A has been achieved, wherein the key step is a highly stereoselective construction of the 6,5,6-dispiroketal (BCD ring) system by an intramolecular hetero-Michael addition of a hemiketal alkoxide reversibly formed under the influence of lithium methoxide.