500535-85-3Relevant academic research and scientific papers
An indium-mediated allylative/transesterification DFT-directed approach to chiral C(3)-functionalized phthalides
Mirabdolbaghi, Roya,Dudding, Travis
, p. 3748 - 3751 (2012)
A one-pot synthesis of chiral C(3)-substituted phthalides via an indium-mediated allylation/transesterification reaction is described. The development of this reaction was facilitated through the applied use of DFT calculations to rationalize the stereoselection of a chiral In-mediated process. It was discovered that the enantiomeric excess of this reaction depended upon the steric size, chain length, and substitution of the aldehyde employed.
THIAZOLE DERIVATIVE AND APPLICATIONS
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Paragraph 0099-0100; 0119-0120, (2019/04/16)
A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
