500544-48-9Relevant academic research and scientific papers
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
Buchanan, John L.,Newcomb, John R.,Carney, David P.,Chaffee, Stuart C.,Chai, Lilly,Cupples, Rod,Epstein, Linda F.,Gallant, Paul,Gu, Yan,Harmange, Jean-Christophe,Hodge, Kathy,Houk, Brett E.,Huang, Xin,Jona, Janan,Joseph, Smriti,Jun, H. Toni,Kumar, Rakesh,Li, Chun,Lu, John,Menges, Tom,Morrison, Michael J.,Novak, Perry M.,Van Der Plas, Simon,Radinsky, Robert,Rose, Paul E.,Sawant, Satin,Sun, Ji-Rong,Surapaneni, Sekhar,Turci, Susan M.,Xu, Keyang,Yanez, Evelyn,Zhao, Huilin,Zhu, Xiaotian
, p. 2394 - 2399 (2011/05/15)
The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, w
