500584-53-2Relevant articles and documents
Asymmetric synthesis of Wieland-Miescher and Hajos-Parrish ketones catalyzed by an amino-acid-derived chiral primary amine
Zhou, Pengxin,Zhang, Long,Luo, Sanzhong,Cheng, Jin-Pei
, p. 2526 - 2530 (2012)
This paper describes a simple chiral primary amine-catalyzed highly efficient and practical protocol for the synthesis of both Wieland-Miescher ketone and Hajos-Parrish ketone as well as their analogues. The reaction can be conducted in gram scale with 1%