5006-69-9

Basic information

• Product Name: Zinc03944768
• Synonyms: Zinc03944768;4-Nitro-1H-iMidazole-1-ethanol;4-NitroiMidazole-1-ethanol;Metronidazole IMpurity C;Metronidazole EP Impurity C;Metronidazole impurity C (EP);2-(4-nitro-1H-imidazol-1-yl)ethan-1-ol
• CAS NO: 5006-69-9
• Molecular Formula: C₅H₇N₃O₃
• Molecular Weight: 157.12738
• Product Categories: Heterocycles
• Mol File: 5006-69-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 117-118 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 425.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly),Chloroform (Slightly), DMSO (Slightly), Methanol (Slight
• PKA: 14.42±0.10(Predicted)
• CAS DataBase Reference: Zinc03944768(CAS DataBase Reference)
• NIST Chemistry Reference: Zinc03944768(5006-69-9)
• EPA Substance Registry System: Zinc03944768(5006-69-9)

Safety Data

• Hazardous Substances Data: 5006-69-9(Hazardous Substances Data)

Usage

Description

Zinc03944768 is a chemical compound with the molecular formula C4H10NO3 and a molecular weight of 119.13 g/mol. It is a derivative of imidazole and contains a nitro group, an ethyl group, and a hydroxyl group. Zinc03944768 has potential applications in various fields, particularly in the development of hypoxic tumor cell radiosensitizers.

Uses

Used in Pharmaceutical Industry:
Zinc03944768 is used as a key intermediate in the synthesis of next-generation hypoxic tumor cell radiosensitizers. These radiosensitizers are designed to enhance the effectiveness of radiation therapy in cancer treatment, particularly for hypoxic (oxygen-deficient) tumor cells that are resistant to conventional radiation therapy. The presence of the nitro group in the compound allows for the generation of reactive nitrogen species upon exposure to radiation, which can increase the radiosensitivity of hypoxic tumor cells and improve the overall therapeutic outcome.
Additionally, the ethyl and hydroxyl groups in Zinc03944768 may contribute to its solubility and stability, making it a suitable candidate for further chemical modifications and optimization to develop more effective and targeted radiosensitizers. Zinc03944768 can also be used as a starting material for the synthesis of other bioactive molecules with potential applications in various therapeutic areas.

Upstream product

• 3034-38-6 1H-4⁽⁵⁾-nitroimidazole 
• 540-51-2 2-bromoethanol 
• 13230-21-2 (4-nitro-imidazol-1-yl)-acetic acid methyl ester 

Downstream Products

• 930100-32-6 C₁₈H₂₂F₂N₄O₃ 
• 1447794-56-0 N-[5-[[3-cyano-7-[[1-(2-hydroxyethyl)imidazol-4-yl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide 

Relevant articles and documents

Artemisinin-indole and artemisinin-imidazole hybrids: Synthesis, cytotoxic evaluation and reversal effects on multidrug resistance in MCF-7/ADR cells

A series of artemisinin derivatives with MDR reversal activity were designed and synthesized. All hybrids were screened to anticancer activities against four human cancer cell lines (A549, MCF-7, HepG-2, MDA-MB-231) and normal human hepatic cell (L02) in vitro. Most of the new compounds showed higher anticancer activities than artemisinin, among which compounds 11a and 11c displayed superior potency with IC50 6.78 μM and 5.25 μM against MCF-7, respectively. The further research indicated that the most potent 11c induced cell cycle arrest at G2 phase in MCF-7. Additionally, compound 11c showed remarkable MDR reversal activity which reversed adriamycin against MCF-7/ADR cells with IC50 0.76 μM.

Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimers disease

The synthesis and structure-activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that contain a β-amine in the imidazole side-chain resulting in a robust in vivo reduction of plasma and brain Aβ in guinea pigs. The therapeutic index between Aβ reductions and changes in B-cell populations were studied for compound 10h.