500699-20-7Relevant academic research and scientific papers
A Highly Photostable Near-Infrared Labeling Agent Based on a Phospha-rhodamine for Long-Term and Deep Imaging
Grzybowski, Marek,Taki, Masayasu,Senda, Kieko,Sato, Yoshikatsu,Ariyoshi, Tetsuro,Okada, Yasushi,Kawakami, Ryosuke,Imamura, Takeshi,Yamaguchi, Shigehiro
, p. 10137 - 10141 (2018)
Various fluorescence microscopy techniques require bright NIR-emitting fluorophores with high chemical and photostability. Now, the significant performance improvement of phosphorus-substituted rhodamine dyes (PORs) upon substitution at the 9-position with a 2,6-dimethoxyphenyl group is reported. The thus obtained dye PREX 710 was used to stain mitochondria in living cells, which allowed long-term and three-color imaging in the vis-NIR range. Moreover, the high fluorescence longevity of PREX 710 allows tracking a dye-labeled biomolecule by single-molecule microscopy under physiological conditions. Deep imaging of blood vessels in mice brain has also been achieved using the bright NIR-emitting PREX 710-dextran conjugate.
“Xanthene” is a premium bridging group for xanthenoid dyes
Li, Jin,Zhang, Mengmeng,Yang, Lu,Han, Yubing,Luo, Xiao,Qian, Xuhong,Yang, Youjun
, p. 3865 - 3869 (2021)
Novel xanthenoid dyes by replacing the central oxygen atom of the xanthene dyes with less electron-rich bridging groups have been intensively sought after primarily for their long spectral wavelengths. However, the new scaffolds are likely prone to nucleophilic attack at their central methane carbon, as the result of the reduced electron density of the fluorochromic scaffolds. We envisage that the bridging group may be harnessed to sterically shield the central methane carbon from incoming nucleophiles and render high stability and synthesized xantheno-xanthene dyes. Additionally, the xantheno-bridging group can be modified via electrophilic aromatic substitution to introduce functionalities, e.g., sulfonate groups.
SILICON-CONTAINING HETEROCYCLIC COMPOUND, AND QUENCHER
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, (2019/08/22)
Quenchers of the related art do not have a quenching ability high enough to sufficiently inhibit the emission of fluorescence from fluorescence compounds. Therefore, the present invention aims to provide a quencher which can sufficiently quench the fluore
Rational design of a fast and selective near-infrared fluorescent probe for targeted monitoring of endogenous nitric oxide
Tang, Junma,Guo, Zhiqian,Zhang, Yutao,Bai, Bing,Zhu, Wei-Hong
, p. 10520 - 10523 (2017/09/29)
The real-time monitoring of nitric oxide (NO) at the subcellular level is still a great challenge. To attain this goal, we developed a fast and selective near-infrared (NIR) fluorescent probe for the targeted tracing of endogenous NO. This probe possesses
Spirolactonized Si-rhodamine: A novel NIR fluorophore utilized as a platform to construct Si-rhodamine-based probes
Wang, Ting,Zhao, Qing-Jie,Hu, Hong-Gang,Yu, Shi-Chong,Liu, Xiang,Liu, Li,Wu, Qiu-Ye
supporting information; experimental part, p. 8781 - 8783 (2012/10/18)
Spirolactonized Si-rhodamine was prepared as a platform to construct Si-rhodamine-based probes by following the design strategy widely used in rhodamine systems. Among them, the reaction-based probe SiR-Hg was operated for NIR sensing and bioimaging of Hg
