500735-16-0Relevant academic research and scientific papers
Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally active inhibitors of lck kinase
Goldberg, Daniel R.,Butz, Tanja,Cardozo, Mario G.,Eckner, Robert J.,Hammach, Abdelhakim,Huang, Jessica,Jakes, Scott,Kapadia, Suresh,Kashem, Mohammed,Lukas, Susan,Morwick, Tina M.,Panzenbeck, Maret,Patel, Usha,Pav, Susan,Peet, Gregory W.,Peterson, Jeffrey D.,Prokopowicz III, Anthony S.,Snow, Roger J.,Sellati, Rosemarie,Takahashi, Hidenori,Tan, Jonathan,Tschantz, Matt A.,Wang, Xiao-Jun,Wang, Yong,Wolak, John,Xiong, Pla,Moss, Neil
, p. 1337 - 1349 (2007/10/03)
The tyrosine kinase p56lck (lck) is essential for T cell activation; thus, inhibitors of lck have potential utility as autoimmune agents. Our initial disclosure of a new class of lck inhibitors based on the phenylaminoimidazoisoquinolin-9-one showed reaso
Isoquinolinone synthesis by SNAr reaction: A versatile route to imidazo[4,5-h]isoquinolin-9-ones
Snow, Roger J.,Butz, Tanja,Hammach, Abdelhakim,Kapadia, Suresh,Morwick, Tina M.,Prokopowicz III, Anthony S.,Takahashi, Hidenori,Tan, Jonathan D.,Tschantz, Matt A.,Wang, Xiao-Jun
, p. 7553 - 7556 (2007/10/03)
Reaction of 2-chlorobenzonitriles with β-ketoesters in an SNAr reaction, followed by cyclization in acid provides a versatile route to isoquinolones. Starting from 2,6-dichloro-3-nitrobenzonitrile 7, sequential displacement of the chlorines by
