333458-39-2

Usage

Uses

Used in Pharmaceutical Synthesis:
6-chloro-2-methylamino-3-nitrobenzonitrile is utilized as a building block in the synthesis of pharmaceuticals. Its unique structure contributes to the development of new drugs, making it a valuable component in medicinal chemistry.
Used in Agrochemical Development:
In the agrochemical industry, 6-chloro-2-methylamino-3-nitrobenzonitrile is used as a starting material for the creation of pesticides. Its reported insecticidal and fungicidal properties render it a promising candidate for the development of novel and effective pest control agents.
Used in Drug Discovery:
6-chloro-2-methylamino-3-nitrobenzonitrile is also studied for its potential in drug discovery. Its distinctive chemical features make it a subject of interest for researchers exploring new therapeutic agents and treatments.
Safety Note:
It is crucial to handle 6-chloro-2-methylamino-3-nitrobenzonitrile with care due to its potential toxicity and harmful effects if not used properly. Adequate safety measures should be taken during its synthesis, application, and disposal to mitigate any risks associated with its use.

InChI:InChI=1/C8H6ClN3O2/c1-11-8-5(4-10)6(9)2-3-7(8)12(13)14/h2-3,11H,1H3

Upstream product

• 5866-98-8 2,6-dichloro-3-nitrobenzonitrile 
• 74-89-5 methylamine 

Downstream Products

• 500735-15-9 2-acetyl-2-(2-cyano-3-methylamino-4-nitro-phenyl)-pentanedioic acid diethyl ester 
• 500735-28-4 2-methylamino-3-nitro-6-(2-oxo-propyl)-benzonitrile 
• 500735-14-8 2-acetyl-2-(2-cyano-3-methylamino-4-nitrophenyl)succinic acid dimethyl ester 
• 333458-86-9 ethyl 1-(4-amino-2-cyano-3-methylaminophenyl)-2-oxo-cyclopentanecarboxylate 
• 500735-26-2 2-(2,6-dichloro-phenylamino)-3-methyl-5-(2-oxo-propyl)-3H-benzoimidazole-4-carbonitrile 
• 333458-88-1 ethyl 1-[4-cyano-2-(2,6-dichlorophenylamino)-3-methyl-3H-benzimidazol-5-yl]-2-oxo-cyclopentanecarboxylate 
• 500735-23-9 2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-pentanedioic acid diethyl ester 
• 333458-41-6 2-(2-cyano-3-methylamino-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester 
• 333455-20-2 2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one 
• 333458-92-7 2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid 
• 500735-22-8 2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester 
• 333455-23-5 2-(2,6-Dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydro-imidazo[4,5-h]isoquinolin-6-acetic acid ethyl ester 

Relevant academic research and scientific papers

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery o

INHIBITORS OF TYROSINE KINASES AND USES THEREOF

Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-rnediated diseases or conditions or tyrosine, kinase-dependent diseases or conditions are provided.

Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally active inhibitors of lck kinase

The tyrosine kinase p56lck (lck) is essential for T cell activation; thus, inhibitors of lck have potential utility as autoimmune agents. Our initial disclosure of a new class of lck inhibitors based on the phenylaminoimidazoisoquinolin-9-one showed reaso

Heterocyclic compounds useful as inhibitors of tyrosine kinases

Disclosed are novel compounds of formula (I): wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases asso

Isoquinolinone synthesis by SNAr reaction: A versatile route to imidazo[4,5-h]isoquinolin-9-ones

Reaction of 2-chlorobenzonitriles with β-ketoesters in an SNAr reaction, followed by cyclization in acid provides a versatile route to isoquinolones. Starting from 2,6-dichloro-3-nitrobenzonitrile 7, sequential displacement of the chlorines by

Heterocyclic compounds useful as inhibitors of tyrosine kinases

Disclosed are novel compounds of formula (I): wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases asso

Heterocyclic compounds useful as inhibitors of tyrosine kinases

Disclosed are novel compounds of formula (I): wherein Ar1, X, Y, P, Q and Het are defined herein, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are pharmaceutical compositions comprising these compounds, processes for preparing these compounds and novel intermediate compounds useful in these processes.