500862-89-5 Usage
Derivative of thiadiazole
Thiadiazole-based It is a chemical compound derived from the thiadiazole ring, which is a five-membered heterocyclic ring containing sulfur and nitrogen atoms.
Amino group presence
Amino (-NH2) group The structure of 2-(5-Amino-[1,3,4]thiadiazol-2-ylsulfanyl)-ethanol contains an amino group, which is a functional group with a nitrogen atom bonded to two hydrogen atoms.
Thiol group presence
Thiol (-SH) group 2-(5-Amino-[1,3,4]thiadiazol-2-ylsulfanyl)-ethanol also contains a thiol group, a functional group with a sulfur atom bonded to a hydrogen atom.
Potential applications
Pharmaceutical and biological research Due to its biological activities, 2-(5-Amino-[1,3,4]thiadiazol-2-ylsulfanyl)-ethanol may have potential uses in the development of new drugs and as a reagent in organic synthesis.
Possible effects and uses
Medicine and industry Further studies on this chemical compound may reveal its potential applications and effects in various fields, including medicine and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 500862-89-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,0,8,6 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 500862-89:
(8*5)+(7*0)+(6*0)+(5*8)+(4*6)+(3*2)+(2*8)+(1*9)=135
135 % 10 = 5
So 500862-89-5 is a valid CAS Registry Number.
500862-89-5Relevant academic research and scientific papers
Synthesis and in vitro evaluation of west nile virus protease inhibitors based on the 1,3,4,5-tetrasubstituted 1H-Pyrrol-2(5H)-one scaffold
Gao, Yaojun,Samanta, Sanjay,Cui, Taian,Lam, Yulin
supporting information, p. 1554 - 1560 (2013/09/12)
West Nile virus (WNV), a member of the Flaviviridae family, is a mosquito-borne pathogen that causes a large number of human infections each year. There are currently no vaccines or antiviral therapies available for human use against WNV. Therefore, efforts to develop new chemotherapeutics against this virus are highly desired. In this study, a WNV NS2B-NS3 protease inhibitor with a 1,3,4,5-tetrasubstituted 1H-pyrrol-2(5H)-one scaffold was identified by screening a small library of nonpeptidic compounds. Optimization of this initial hit by the synthesis and screening of a focused library of compounds with this scaffold led to the identification of a novel uncompetitive inhibitor ((-)-1a16, IC50=2.2±0.7μM) of the WNV NS2B-NS3 protease. Molecular docking of the chiral compound onto the WNV protease indicates that the Renantiomer of 1a16 interferes with the productive interactions between the NS2B cofactor and the NS3 protease domain and is thus the preferred isomer for inhibition of the WNV NS2B-NS3 protease.
