501014-34-2Relevant academic research and scientific papers
A new laboratory scale synthesis for the anticancer drug 3′-C-ethynylcytidine
Ludwig, Peter S.,Schwendener, Reto A.,Schott, Herbert
, p. 2387 - 2392 (2007/10/03)
A new synthetic route for the preparation of larger quantities of the anticancer nucleoside analogue 3′-C-ethynylcytidine is described. Starting from cytidine which was orthogonally protected in three steps, the ketonucleoside analogue as the key intermediate was obtained through oxidation of the unprotected 3′-hydroxy group. Stereoselective addition of the trimethylsilyl-protected acetylide residue at the 3′-carbonyl group followed by a complete deprotection afforded 3′-C-ethynylcytidine in an overall yield of 24% in seven steps.
