72409-30-4

Upstream product

• 93-97-0 benzoic acid anhydride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 72409-15-5 N⁴-benzoyl-5'-O-(4-monomethoxytrityl)cytidine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 16640-05-4 1-(β-D-arabinofuranosyl)-N⁴-benzoylcytosine 
• 87418-75-5 N⁴-benzoyl-5'-O-monomethoxytritylarabinocytidine 
• 65-46-3 CYTIDINE 
• 13089-48-0 N₄-benzoylcytidine 

Downstream Products

• 76101-37-6 C₆₅H₈₉N₈O₁₃PSi₃ 
• 72599-85-0 C₆₆H₈₈Cl₃N₈O₁₃PSi₃ 
• 76101-35-4 C₆₇H₉₀N₉O₁₃PSi₃ 
• 76101-36-5 C₇₀H₉₀ClN₈O₁₃PSi₃ 
• 76101-34-3 C₇₁H₉₃N₈O₁₃PSi₃ 
• 76101-33-2 C₆₆H₈₈Br₃N₈O₁₃PSi₃ 
• 79607-32-2 3'-methylchlorophosphite of 5'-monomethoxytrityl-2'-TBDMS-N-benzoylcytidine 
• 101904-22-7 N⁴-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)cytidine 3'-N,N-diisopropylmethylphosphoramidite 
• 101904-18-1 N⁴-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)cytidine 3'-N-morpholinomethylphosphoramidite 
• 72409-29-1 4-Amino-1-{(2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one 
• 72409-28-0 4-Amino-1-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one 
• 501014-32-0 N⁴-benzoyl-2'-O-(tert-butyldimethylsilyl)-3'-keto-5'-O-(4-monomethoxytrityl)cytidine 
• 72624-28-3 C₄₆H₇₂Cl₃N₈O₁₂PSi₃ 
• 2382-66-3 Cytidin-(3',5')-adenosin 

Relevant academic research and scientific papers

A new laboratory scale synthesis for the anticancer drug 3′-C-ethynylcytidine

A new synthetic route for the preparation of larger quantities of the anticancer nucleoside analogue 3′-C-ethynylcytidine is described. Starting from cytidine which was orthogonally protected in three steps, the ketonucleoside analogue as the key intermediate was obtained through oxidation of the unprotected 3′-hydroxy group. Stereoselective addition of the trimethylsilyl-protected acetylide residue at the 3′-carbonyl group followed by a complete deprotection afforded 3′-C-ethynylcytidine in an overall yield of 24% in seven steps.

The preparation of protected arabinonucleosides

A general procedure is described for the preparation of protected arabinonucleosides.Protection at the 5'-position involves triphenylmethyl groups (DMT and MMT) while the tert-butyldimethylsilyl (TBDMS) group is used to protect the 2'- or 3'-positions.The

Nucleosides, XXXVII. - Synthesis and Properties of 2'-O- and 3'-O-(tert-Butyldimethylsilyl)-5'-O-(4-methoxytrityl)- and 2',3'-Bis(O-tert-butyldimethylsilyl)ribonucleosides - Starting Materials for Oligoribonucleotide Syntheses

The synthesis of aminoacylated 5'-O-(4-methoxytrityl)ribonucleosides of adenosine (1), guanosine (9), cytidine (31), uridine (17), and 5,6-dihydrouridine (23) have been optimized and these compounds (4, 12, 33, 18 and 24) silylated by tert-butyldimethylsilyl chloride.The corresponding 2'- and 3'-mono-O- as well as 2',3'-bis-O-(tert-butyldimethylsilyl) derivatives have been isolated by combination of chromatographical methods and fractional crystallization procedures in preparative scale.The characterization of the newly synthesized compounds was achieved by UV and 13C-NMR spectra.