501015-40-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 51531-21-6 3-boryl-1-propene 
• 183293-41-6 (S)-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal 
• 106356-53-0 B-allyldiisopinocampheylborane 
• 84341-89-9 (2S)-(+)-2-methyl-3-(toluene-4-sulfonyloxy)propionic acid methyl ester 
• 85116-38-7 (+)-diisopinocampheylallylborane 

Downstream Products

• 944154-87-4 (2S,3S)-3-(tert-butyldimethylsilyloxy)-2-methylhex-5-enyl 4-methylbenzenesulfonate 
• 1361551-05-4 (2S)-2-((2R,7S,8S,E)-8-(tert-butyldimethylsilyloxy)-7-methyl-12-oxo-1-oxacyclododec-4-en-2-yl)propyl-4-methylbenzene-1-sulfonate 
• 1361551-13-4 (5S,6S)-5-(tert-butyldimethylsilyloxy)-6-methyl-7-(tosyloxy)heptanoic acid 
• 1436866-91-9 C₂₁H₃₄O₆SSi 
• 501015-58-3 (-)-2-methylpent-4-enoic acid [(2S,3S,4R,2'R,4'S,5'S)-1-(5-allyl-4-methyltetrahydrofuran-2-yl)-2-(tert-butyldiphenylsilanyloxy)-3-methoxymethoxy-4-methyl-6-one]undec-8-yl ester 
• 501015-55-0 (2S,3S,4R,2'R,4'S,5'S)-(-)-1-(5-allyl-4-methyltetrahydrofuran-2-yl)-5-(tert-butyldimethylsilanyloxy)-2-(tert-butyldiphenylsilanyloxy)-3-methoxymethoxy-4-methylpentane 
• 501015-57-2 (2S,3S,4R,2'R,4'S,5'S)-(-)-1-(5-allyl-4-methyltetrahydrofuran-2-yl)-2-(tert-butyldiphenylsilanyloxy)-3-methoxymethoxy-4-methyl-5-iodopentane 
• 501015-56-1 (2S,3S,4R,2'R,4'S,5'S)-(-)-1-(5-allyl-4-methyltetrahydrofuran-2-yl)-2-(tert-butyldiphenylsilanyloxy)-3-methoxymethoxy-4-methylpentan-5-ol 
• 646030-69-5 (2R,3S,4S,2'R,4'S,5'S)-(-)-[5-(5-allyl-4-methyltetrahydrofuran-2-yl)-4-(4-methoxybeznyloxy)-3-methoxymethoxy-4-methylpentyloxy]tert-butyldimethylsilane 
• 501015-64-1 [(1S,2S)-1-((2R,4S,5S)-5-Allyl-4-methyl-tetrahydro-furan-2-ylmethyl)-2-methoxymethoxy-3-methyl-butoxy]-tert-butyl-diphenyl-silane 
• 646030-55-9 (2R,3S,4S,2'R,4'S,5'S)-5-(5-allyl-4-methyltetrahydrofuran-2-yl)-4-(4-methoxybenzyloxy)-3-methoxymethoxy-4-methylpentan-1-ol 
• 501015-43-6 (2S,3S)-2-allyl-5-benzenesulfonyl-3-methyltetrahydrofuran 

Relevant academic research and scientific papers

Modular total syntheses of mycolactone A/B and its [2H]-isotopologue

A modular total synthesis of mycolactone A/B, the exotoxin produced by Mycobacterium ulcerans, has been achieved through the orchestration of several Pd-catalyzed key steps. While this route leads to a mixture of the natural product and its C12 epimer (4:

STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN

The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y-O-W (I), wherein Y and W are as defined in claim 1.

Structural variants of mycolactones for use in modulating inflammation, immunity and pain

The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. ???????? Y-O-W?????(I) wherein Y and W are as defined in claim 1.

A diverted total synthesis of mycolactone analogues: An insight into buruli ulcer toxins

Mycolactones are complex macrolides responsible for a severe necrotizing skin disease called Buruli ulcer. Deciphering their functional interactions is of fundamental importance for the understanding, and ultimately, the control of this devastating mycobacterial infection. We report herein a diverted total synthesis approach of mycolactones analogues and provide the first insights into their structure-activity relationship based on cytopathic assays on L929 fibroblasts. The lowest concentration inducing a cytopathic effect was determined for selected analogues, allowing a clear picture to emerge by comparison with the natural toxins.

Total Syntheses of Amphidinolide T1, T3, T4, and T5

A concise, flexible, and high yielding entry into the family of amphidinolide T macrolides, a series of cytotoxic natural products of marine origin, has been developed. All individual members, except amphidinolide T3 (3), derive from compound 39 as a comm

Total synthesis of amphidinolide T4

Organometallic chemistry in general and catalysis in particular are used in the first total synthesis of amphidinolide T4 (see scheme); a prototype member of a series of macrolide antibiotics of marine origin with rings containing an odd number of carbon