501074-90-4

Upstream product

• 110-71-4 1,2-dimethoxyethane 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 110-86-1 pyridine 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 1692-15-5 4-pyridylboronic acid 
• 1120-87-2 4-bromopyridin 
• 19524-06-2 4-bromopyridine hydrochloride 

Downstream Products

• 545395-97-9 4-(4-tert-butyl-phenyl)pyridine 1-oxide 
• 545395-99-1 2-bromo-4-(4-tert-butyl-phenyl)pyridine 

Relevant academic research and scientific papers

Organic light-emitting material based on platinum quadridentate ONCN complex, preparation method, and application of the same in organic light emitting diodes (OLEDs)

The invention relates to an organic light-emitting material based on a platinum quadridentate ONCN complex, a preparation method, and an application of the same in OLEDs. The platinum (II) quadridentate ONCN complex has the chemical structure of the formu

Mild, visible light-mediated decarboxylation of aryl carboxylic acids to access aryl radicals

Herein we present the first example of aryl radical formation via the visible light-mediated decarboxylation of aryl carboxylic acids using photoredox catalysis. This method constitutes a mild protocol for the decarboxylation of cheap and abundant aryl carboxylic acids and tolerates both electron-rich substrates and those lacking ortho-substitution. The in situ formation of an acyl hypobromite is proposed to prevent unproductive hydrogen atom abstraction and trapping of the intermediate aroyloxy radical, enabling mild decarboxylation.

Cp2Ni-KOt-Bu-BEt3 (or PPh3) catalyst system for direct C - H arylation of benzene, naphthalene, and pyridine

Ni-catalyzed direct C - H arylation of benzene and naphthalene using aryl halides was investigated. For the first time, the arylation was successfully catalyzed by Cp2Ni (5 mol %) in the presence of KOt-Bu and BEt 3. This Ni catalyst system was also applied to direct C - H arylation of pyridine, an electron-deficient heteroarene; PPh3 was used instead of BEt3 in this case.

Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides

The vanilloid receptor-1 (VR1 or TRPV1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role as an integrator of multiple pain-producing stimuli. From a high-throughput screening assay, measuring calcium uptake in

Modulation of the reactivity, stability and substrate- and enantioselectivity of an epoxidation catalyst by noncovalent dynamic attachment of a receptor functionality - Aspects on the mechanism of the Jacobsen-Katsuki epoxidation applied to a supramolecular system

The synthesis of the components of the dynamic supramolecular hydrogen-bonded catalytic system 2 + 3 is described. The catalytic performance and substrate- and enantioselectivity of Mn(salen) catalyst 2 were investigated in the presence and absence of the Zn(porphyrin) receptor unit 3. The effects of pyridine and pyridine N-oxide donor ligands were also studied. Some aspects on the mechanism of the Jacobsen-Katsuki epoxidation, based on literature observations, are introduced as a means to analyse the behaviour of 2 and its modulation by the formation of macrocycle 1 with 3. A complete association model of the metal-free system 4 + 5 refutes the earlier assumption that macrocycle 1 is the predominant form of catalyst 2 under the standard epoxidation reaction conditions with 2 + 3. Evidence are provided that receptor-binding substrates and nonbinding substrates, respectively, are epoxidised by two different catalytic species, or two distinct distributions of species in competitive epoxidations using catalytic system 2 + 3. The two species are assigned to the endo and exo faces of the Mn(salen) catalyst in macrocycle 1, and to equivalently folded oligomeric structures with monomers 2 and 3 in adjacent positions. The Royal Society of Chemistry 2006.

A dynamic supramolecular system exhibiting substrate selectivity in the catalytic epoxidation of olefins

A dynamic supramolecular system involving hydrogen bonding between a Mn(III) salen catalyst and a Zn(II) porphyrin receptor exhibits selectivity for pyridine appended cis-β-substituted styrene derivatives over phenyl appended derivatives in a catalytic ep

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.