501089-70-9

Upstream product

• 100-39-0 benzyl bromide 
• 220645-16-9 4-methylphenyl 4,6-O-benzylidene-2-deoxyl-1-thio-2-phthalimido-β-D-glucopyranoside 
• 172847-90-4 p-methylphenyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside 

Downstream Products

• 1169693-80-4 5-azidopentyl-O-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 852570-14-0 3-(benzyloxycarbonylamino)propyl 3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 502692-44-6 p-tolyl 3,6-di-O-benzyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxy)carbamoylamino-β-D-glucopyranoside 
• 905267-00-7 p-tolyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-1-thio-2-(2,2,2-trichloroethoxy)carbamoylamino-β-D-glucopyranoside 
• 852570-13-9 3-(benzyloxycarbonylamino)propyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 807361-23-5 p-tolyl 3,6-di-O-benzyl-2-deoxy-2-N-phthalimido-1-thio-β-D-glucopyranoside 

Relevant academic research and scientific papers

One-Pot Glycosylation Strategy Assisted by Ion Mobility-Mass Spectrometry Analysis toward the Synthesis of N-Linked Oligosaccharides

N-Glycans are major constituents of several cellular glycoproteins. One-pot strategies for the synthesis of N-glycans are crucial for the rapid generation of pure samples to determine their biological functions. Herein, we describe a double one-pot strategy for the synthesis of N-glycans assisted by an IM-MS analysis approach for rapid screening of optimized glycosylation reaction conditions. This research includes triflate-mediated direct β-mannosylation and tandem glycosylation in a one-pot strategy for the synthesis of the challenging N-linked trisaccharide core β-5. Furthermore, a one-pot sequential glycosylation of the N-linked trisaccharide core 7 furnishes diverse high-mannose type N-glycans with excellent stereo- and regioselectivities. In particular, ion mobility-mass spectrometry-based quantitative analysis is applied to identify the stereo- and regioselective outcomes of the crude reaction mixtures to develop a highly efficient one-pot protocol.

Efficient convergent synthesis of Bi-, Tri-, and tetra-antennary complex type N-glycans and their HIV-1 antigenicity

The structural diversity of glycoproteins often comes from post-translational glycosylation with heterogeneous N-glycans. Understanding the complexity of glycans related to various biochemical processes demands a well-defined synthetic sugar library. We r

Iterative one-pot syntheses of chitotetroses

Rapid syntheses of chitotetrose derivatives were achieved in good yields using the newly developed reactivity independent iterative one-pot strategy. The protective groups on donors and acceptors were independently evaluated allowing matching of the two p

A new one-pot synthesis of α-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation

Xenotransplantations from pig to human are rapidly rejected because of the interaction between α-Gal epitopes carried by the graft and natural antibodies (anti-Gal antibodies) present in the blood of the recipient. This paper describes a three-component o

A four-component one-pot synthesis of α-Gal pentasaccharide

(Chemical equation presented) A four-component one-pot sequential synthesis of α-Gal pentasaccharide 2 with minimal protecting group manipulations in a very short period of time is described in this paper.