501098-88-0Relevant academic research and scientific papers
Benzannulation of substituted 3-alkoxycarbonylhex-3-en-5-ynoic acids: A new route to 4-substituted 3,5-dihydroxybenzoic acids derivatives
Serra, Stefano,Fuganti, Claudio
, p. 1661 - 1664 (2002)
A new regioselective pathway to 4-substituted 3,5-dihydroxybenzoic acids derivatives is described here. According to this procedure substituted propargylic aldehydes are converted into substituted 3-alkoxycarbonylhex-3-en-5-ynoic acids, which are in turn, treated with acetic anhydride in the presence of sodium acetate to give the substituted benzoic acids derivatives. The aromatic moiety constructed using the latter benzannulation reaction is formed in regioselective fashion and a range of substituents are tolerated.
Cascade reaction including a formal [5?+?2] cycloaddition by use of alkyne-Co2(CO)6 complex
Sakata, Yuki,Yasui, Eiko,Mizukami, Megumi,Nagumo, Shinji
, p. 755 - 759 (2019/02/20)
A new cascade reaction including formal [5 + 2] cycloaddition was developed. Treatment of homocinnamyl alcohol and Co2(CO)6-complexed arylpropynal with BF3·OEt2 resulted in the generation of hydrobenzocyclohepta
