501127-42-0Relevant articles and documents
Novel scaffold for cathepsin K inhibitors
Teno, Naoki,Miyake, Takahiro,Ehara, Takeru,Irie, Osamu,Sakaki, Junichi,Ohmori, Osamu,Gunji, Hiroki,Matsuura, Naoko,Masuya, Keiichi,Hitomi, Yuko,Nonomura, Kazuhiko,Horiuchi, Miyuki,Gohda, Keigo,Iwasaki, Atsuko,Umemura, Ichiro,Tada, Sachiyo,Kometani, Motohiko,Iwasaki, Genji,Cowan-Jacob, Sandra W.,Missbach, Martin,Lattmann, Rene,Betschart, Claudia
, p. 6096 - 6100 (2008/04/03)
Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.