864655-05-0

Basic information

• Product Name: 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine
• Synonyms: 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine;5-bromo-2-chloro-N-cyclohexylpyrimidin-4-amine
• CAS NO: 864655-05-0
• Molecular Formula: C₁₀H₁₃BrClN₃
• Molecular Weight: 290.58732
• Mol File: 864655-05-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine(864655-05-0)
• EPA Substance Registry System: 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine(864655-05-0)

Safety Data

• Hazardous Substances Data: 864655-05-0(Hazardous Substances Data)

Usage

General Description

5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine is a chemical compound with the molecular formula C11H13BrClN3. It is a pyrimidine derivative with a bromo, chloro, and cyclohexyl substituent attached to the pyrimidine ring. 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine is commonly used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. It is also used in the production of dyes and pigments. 5-bromo-2-chloro-N-cyclohexy-4-Pyrimidinamine is an important building block in organic chemistry and is widely used in the pharmaceutical and agrochemical industries for the development of new drugs and crop protection products.

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 108-91-8 cyclohexylamine 

Downstream Products

• 501127-42-0 5-bromo-4-cyclohexylamino-pyrimidine-2-carbonitrile 
• 1588959-33-4 C₁₅H₁₇N₅ 

Relevant articles and documents

Design and Synthesis of Novel 2,4-Diamino-5-pyrazol-4-yl Pyrimidine Derivatives as Selective Tyro3 Kinase Inhibitors

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Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents

With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and extensive drug-resistant strains (XDR-TB), there is an urgent need to develop novel drugs for the treatment of tuberculosis. Here, we designed and synthesized a series of 5-methylpyrimidopyridone analogues as potential antitubercular agents. The most potent compound 6q exhibited a MIC value of 4 μM in vitro against Mycobacterium tuberculosis. The antitubercular activities of the synthesized compounds were impacted by the amantadine and 2-chlorophenyl groups, and were enhanced by the presence of 3-methyl(4-dimethylamino)piperidinylphenyl. Molecular modeling and binding studies suggest that PknB is the potential molecular target of 5-methylpyrimidopyridone compounds. This study provides insights for the future development of new antimycobacterial agents with novel mechanisms of action.

Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads

Mps1, also known as TTK, is a mitotic checkpoint protein kinase that has become a promising new target of cancer research. In an effort to improve the lead-likeness of our recent Mps1 purine lead compounds, a scaffold hopping exercise has been undertaken.