501170-72-5

Upstream product

• 19810-31-2 Benzyloxyacetyl chloride 
• 158205-19-7 5-Amino-6-bromo-1-indanone 
• 158205-18-6 5-Acetylamino-6-bromo-1-indanone 
• 30379-55-6 benzyloxyacetic acid 

Downstream Products

• 1356166-12-5 5-(benzyloxyacetamido)-6-cyanoindan-1-one 
• 1356166-13-6 6-aminocarbonyl-5-(benzyloxyacetamido)-indan-1-one 
• 501170-85-0 tert-butyl 4-{N-[2-benzyloxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate 
• 501170-80-5 tert-butyl 4-[N-(5-(2-benzyloxy-ethanoylamino)-6-cyanoindan-1-yl)amino]benzoate 
• 501132-07-6 tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoate 
• 501170-90-7 tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate 
• 501170-76-9 tert-butyl 4-[N-(5-(2-benzyloxy-ethanoylamino)-6-bromoindan-1-yl)amino]benzoate 

Relevant academic research and scientific papers

Cyclopenta[g]quinazolinone-based inhibitors of thymidylate synthase targeting α-folate receptor overexpressing tumours: synthetic approaches to 4-{N-[(6RS)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benz

An advanced intermediate for the synthesis of cyclopenta[g]quinazolinone-based antifolates such as (6RS)-CB300945 was prepared by a convergent methodology. The oxo-functionality required for the formation of the C-6-N-10 bond in 4 was introduced in the in

SYNTHESIS OF CYCLOPENTAQUINAZOLINES

A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4- [N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin