158205-19-7 Usage
Description
5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one is a chemical compound that belongs to the class of inden-1-one derivatives. It is characterized by its yellow solid appearance and a unique molecular structure with the formula C9H8BrNO, resulting in a molecular weight of 228.07 g/mol. This synthetic intermediate is pivotal in organic synthesis and pharmaceutical research, offering a broad spectrum of potential applications due to its distinctive chemical properties and reactivity.
Uses
Used in Pharmaceutical Research and Development:
5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one is utilized as a synthetic intermediate for the development of new drugs. Its unique chemical structure and reactivity make it a valuable component in the creation of pharmaceutical compounds, potentially leading to advancements in medicinal chemistry.
Used in Agrochemical Development:
In the agrochemical industry, 5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one serves as a key intermediate in the synthesis of various agrochemicals. Its application is crucial for the development of new pesticides, herbicides, and other agricultural chemicals that can improve crop protection and yield.
Used in Organic Synthesis:
5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one is employed as a versatile building block in organic synthesis. Its unique properties allow it to be a component in the creation of a wide range of organic compounds, contributing to the advancement of organic chemistry and the discovery of new chemical entities.
Used in Research and Development:
5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one is of significant interest to researchers and chemists in the field of organic chemistry. It is used as a subject of study to explore new reactions, mechanisms, and applications, furthering the understanding of chemical processes and potentially uncovering new uses and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 158205-19-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,2,0 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 158205-19:
(8*1)+(7*5)+(6*8)+(5*2)+(4*0)+(3*5)+(2*1)+(1*9)=127
127 % 10 = 7
So 158205-19-7 is a valid CAS Registry Number.
158205-19-7Relevant articles and documents
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity
Rajapaksa, Naomi S.,Gobbi, Alberto,Drobnick, Joy,Do, Steven,Kolesnikov, Aleksandr,Liang, Jun,Chen, Yongsheng,Sujatha-Bhaskar, Swathi,Huang, Zhiyu,Brightbill, Hans,Francis, Ross,Yu, Christine,Choo, Edna F.,Dement, Kevin,Ran, Yingqing,An, Le,Emson, Claire,Maher, Jonathan,Wai, John,McKenzie, Brent S.,Lupardus, Patrick J.,Zarrin, Ali A.,Kiefer, James R.,Bryan, Marian C.
supporting information, p. 327 - 333 (2019/12/02)
IRAK4 kinase activity transduces signaling from multiple IL-1Rs and TLRs to regulate cytokines and chemokines implicated in inflammatory diseases. As such, there is high interest in identifying selective IRAK4 inhibitors for the treatment of these disorders. We previously reported the discovery of potent and selective dihydrobenzofuran inhibitors of IRAK4. Subsequent studies, however, showed inconsistent inhibition in disease-relevant pharmacodynamic models. Herein, we describe application of a human whole blood assay to the discovery of a series of benzolactam IRAK4 inhibitors. We identified potent molecule 19 that achieves robust in vivo inhibition of cytokines relevant to human disease.
PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
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Page/Page column 749, (2017/07/14)
Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
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, (2008/06/13)
The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.
