5013-77-4

Usage

Uses

Used in Pharmaceutical Industry:
(2,4-Dichlorobenzyl)methylamine is used as a precursor in the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives. These derivatives are known for their potential pharmaceutical applications, including the development of new drugs with various therapeutic effects. (2,4-Dichlorobenzyl)methylamine's reactivity and structural features allow for the creation of a diverse range of pyrazinone-based molecules with different biological activities.
Used in Chemical Synthesis:
In the chemical industry, (2,4-Dichlorobenzyl)methylamine serves as an intermediate in the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, leading to the production of a wide array of specialty chemicals with specific applications in areas such as materials science, agrochemicals, and dyes.

InChI:InChI=1/C8H9Cl2N/c1-11-5-6-2-3-7(9)4-8(6)10/h2-4,11H,5H2,1H3/p+1

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 74-89-5 methylamine 
• 17972-00-8 N-Methyl-2,4-dichlorbenzylidenamin 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 90842-50-5 dichloro-acetic acid-[(2,4-dichloro-benzyl)-methyl-amide] 
• 55245-70-0 C₉H₈Cl₃NO 
• 543739-85-1 N-(4-{2-[(2,4-dichloro-benzyl)-methyl-amino]-acetyl}-phenyl)-acetamide 
• 1021527-12-7 N-2,4-(dichlorobenzyl)-N,3,5-trimethyl-4-(phenylsulfonyl)-1H-pyrrole-2-carboxamide 
• 1021525-86-9 N-(2,4-dichlorobenzyl)-N,3-dimethyl-4-(1-phenylsulfonyl)-1H-pyrrole-2,5-dicarboxamide 
• 1174903-45-7 3-[[(2,4-dichlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 543739-86-2 2-((2,4-dichlorobenzyl)(methyl)amino)-1-phenylethanone 
• 543739-89-5 1-(4-bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone 
• 1234367-16-8 2-((2,4-dichlorobenzyl)(methyl)amino)-1-(3-nitrophenyl)ethanone 
• 1234366-96-1 1-(3-bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone 

Relevant academic research and scientific papers

AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES

Compounds are disclosed that have a formula represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example inflammatory conditions, infectious diseases, autoimmune diseases, diseases involving impairment of immune cell functions, cardiometabolic diseases, and/or proliferative diseases.

Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations

3H-1,3,4-Oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the reference strain of Mycobacterium tuberculosis H37Rv. Molecular modeling investigations were performed and showed that the active compounds possess all necessary features to target the protein active site of the mycobacterial cytochrome P450-dependent sterol 14α-demethylase in the sterol biosynthesis pathway as the calculated free energy of binding were in agreement with the corresponding MIC values.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.