5013-77-4

Basic information

• Product Name: (2,4-Dichlorobenzyl)methylamine
• Synonyms: (2,4-DICHLOROBENZYL)METHYLAMINE;2,4-DICHLORO-N-METHYLBENZYLAMINE;N-(2,4-DICHLOROBENZYL)-N-METHYLAMINE;(2,4-Dichlorobenzyl)methylamine95%;(2,4-DICHLOROBENZYL)METHYLAMINE 95%;(2,4-dichlorophenyl)-N-methylmethanamine;90389-07-4 (Hydrochloride);Aids107211
• CAS NO: 5013-77-4
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.07
• Product Categories: Amines and Anilines;API intermediates
• Mol File: 5013-77-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 123°C/13mmHg(lit.)
• Flash Point: 99.3 ºC
• Appearance: Colorless/Low Melting Solid
• Density: 1.226 g/cm³
• Vapor Pressure: 0.0376mmHg at 25°C
• Refractive Index: 1.5560 to 1.5600
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.44±0.10(Predicted)
• CAS DataBase Reference: (2,4-Dichlorobenzyl)methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-Dichlorobenzyl)methylamine(5013-77-4)
• EPA Substance Registry System: (2,4-Dichlorobenzyl)methylamine(5013-77-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39
• RIDADR: UN 2735 8/PG III
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 5013-77-4(Hazardous Substances Data)

Usage

Uses

(2,4-Dichlorobenzyl)methylamine is a precursor used in the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives.

InChI:InChI=1/C8H9Cl2N/c1-11-5-6-2-3-7(9)4-8(6)10/h2-4,11H,5H2,1H3/p+1

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 74-89-5 methylamine 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 17972-00-8 N-Methyl-2,4-dichlorbenzylidenamin 

Downstream Products

• 90842-50-5 dichloro-acetic acid-[(2,4-dichloro-benzyl)-methyl-amide] 
• 1234366-96-1 1-(3-bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone 
• 1234367-16-8 2-((2,4-dichlorobenzyl)(methyl)amino)-1-(3-nitrophenyl)ethanone 
• 543739-89-5 1-(4-bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone 
• 543739-86-2 2-((2,4-dichlorobenzyl)(methyl)amino)-1-phenylethanone 
• 1174903-45-7 3-[[(2,4-dichlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1021525-86-9 N-(2,4-dichlorobenzyl)-N,3-dimethyl-4-(1-phenylsulfonyl)-1H-pyrrole-2,5-dicarboxamide 
• 1021527-12-7 N-2,4-(dichlorobenzyl)-N,3,5-trimethyl-4-(phenylsulfonyl)-1H-pyrrole-2-carboxamide 
• 543739-85-1 N-(4-{2-[(2,4-dichloro-benzyl)-methyl-amino]-acetyl}-phenyl)-acetamide 

Relevant articles and documents

AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES

Compounds are disclosed that have a formula represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example inflammatory conditions, infectious diseases, autoimmune diseases, diseases involving impairment of immune cell functions, cardiometabolic diseases, and/or proliferative diseases.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.