501335-21-3

Upstream product

• 42348-86-7 5-chloro-1-indanone 
• 620-05-3 iodomethylbenzene 

Downstream Products

• 1376128-68-5 N-(2-benzyl-6-chloro-1H-inden-3-yl)benzamide 
• 1376128-33-4 (R)-N-(2-benzyl-5-chloro-2-fluoro-2,3-dihydro-1H-inden-1-ylidene)benzamide 

Relevant academic research and scientific papers

Chemoenzymatic synthesis and resolution of compounds containing a quaternary stereocenters adjacent to a carbonyl group

Racemic compounds containing a quaternary stereocenter (having hydroxymethyl and alkyl group adjacent to keto functionality) based on chromanone, α-tetralone, and indalone scaffolds have been synthesized. An enzymatic irreversible transesterification approach has been applied to generate the pure enantiomers in a stereocontrolled fashion. The pure enantiomers of some α,α-dialkylated carbonyl compounds have been synthesized by this method.

C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals

The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful for reducing weight, for the prophylaxis or treatment of obesity, and for the prophylaxis or treatment of type II diabetes in mammals. The invention is directed also to methods for reducing weight and such treatments and prophylaxis. The invention is directed also to processes for the preparation of such compounds.