501357-89-7

Basic information

• Product Name: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine
• Synonyms: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine;8-Chloro[1,2,4]triazolo[4,3-a]pyridine 98%;8-chloro-[1, 2, 4] triazolopyridine;8-Chloro[1,2,4]triazolo[4,3-a]pyridine98%
• CAS NO: 501357-89-7
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.56906
• Product Categories: blocks;Pyridines;Heterocycle-Pyridine series
• Mol File: 501357-89-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 184-186
• Appearance: /
• Density: 1.51 g/cm³
• Refractive Index: 1.712
• Storage Temp.: Keep Cold
• PKA: 2.02±0.50(Predicted)
• CAS DataBase Reference: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine(501357-89-7)
• EPA Substance Registry System: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine(501357-89-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 501357-89-7(Hazardous Substances Data)

Usage

General Description

8-Chloro[1,2,4]triazolo[4,3-a]pyridine is a chemical compound with the molecular formula C6H4ClN3. It belongs to the class of pyridine derivatives and contains a chlorine atom and a triazolopyridine ring. 8-Chloro[1,2,4]triazolo[4,3-a]pyridine is commonly used in the pharmaceutical industry for the synthesis of various biologically active molecules. It has potential applications in drug discovery and development, particularly in the design of novel drugs for the treatment of diseases such as cancer, inflammation, and neurological disorders. Its unique structure and chemical properties make it a valuable building block in organic synthesis and medicinal chemistry. Additionally, its biological activity and pharmacological properties make it a subject of interest for research and development in the field of medicinal chemistry.

InChI:InChI=1/C6H4ClN3/c7-5-2-1-3-10-4-8-9-6(5)10/h1-4H

Upstream product

• 22841-92-5 (3-chloro-2-pyridyl)hydrazine 
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• 2402-77-9 2,3-dichloro-pyridine 
• 50-00-0 formaldehyd 
• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 
• 64-18-6 formic acid 

Relevant articles and documents

Microwave assistant one pot synthesis, crystal structure, antifungal activities and 3D-QSAR of novel 1,2,4-triazolo[4,3-a]pyridines

A series of novel 1,2,4-triazolo[4,3-a]pyridines were synthesized, and their structures were characterized by 1H NMR, MS, elemental analysis, and single-crystal X-ray diffraction analysis. The antifungal activities were evaluated. The antifungal activity results indicated that the compound 2b, 2g, 2p, and 2i exhibited good activities. The activity of compound 2b, 2g, 2p, and 2i can compare with the commercial pesticide. The 3D-QSAR model was developed using CoMFA method. Both the steric and electronic field distributions of CoMFA are in good agreement in this work and will be very helpful in designing a new set of analogues. A series of novel 1,2,4-triazolo[4,3-a]pyridines were synthesized. The antifungal activity results indicated that the compounds 2b, 2g, 2p, and 2i exhibited good activities. The activity of compounds 2b, 2g, 2p, and 2i can compare with the commercial pesticide. The 3D-QSAR model was developed using CoMFA method.

Copper(i)-catalyzed benzylation of triazolopyridine through direct C-H functionalization

A general and efficient copper-catalyzed benzylation reaction of triazolopyridine with N-tosylhydrazones was developed. This reaction forms a C(sp2)-C(sp3) bond through cross-coupling, and represents an exceedingly practical method t