501358-04-9

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 100-61-8 N-methylaniline 
• 172983-98-1 1-(4-Bromo-phenyl)-2-[(2-iodo-phenyl)-methyl-amino]-ethanone 
• 615-43-0 2-iodophenylamine 
• 57056-93-6 N-methyl-2-iodoaniline 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 172984-02-0 N-(2-iodoanilinomethyl)succinimide 

Downstream Products

• 1401615-95-9 (4-bromophenyl)(1-(methyl(phenyl)amino)cyclopropyl)methanone 
• 51206-91-8 3-(4-bromophenyl)-1-methyl-1H-indole 
• 1127405-08-6 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione 

Relevant academic research and scientific papers

N-Bromosuccinimide promoted and base switchable one pot synthesis of α-imido and α-amino ketones from styrenes

An N-Bromosuccinimide (NBS) promoted one pot strategy for the synthesis of α-amino functionalized aryl ketones starting from commercially available styrenes has been developed. NBS participates in multiple tasks, such as bromonium ion formation, oxidation of bromohydrin and providing a nucleophilic nitrogen source. The reaction can easily be switched between α-imido and α-amino ketones by the choice of base. This one pot strategy was successfully applied for the synthesis of psychoactive drug candidates, amfepramone, mephedrone and 4-MEC.

Synthesis of α-Keto Amides by a Pyrrolidine/TEMPO-Mediated Oxidation of α-Keto Amines

A mild procedure has been developed for the synthesis of α-keto amides by α-oxidation of the corresponding α-keto amines mediated by pyrrolidine and TEMPO. The method can also be applied to the synthesis of α-keto thioamides and α-keto amidines.

A NEW SYNTHESIS OF 3-SUBSTITUTED INDOLINES AND INDOLES

3-Phenyl- and 3-alkyl-3-hydroxyindolines were synthesized by intramolecular Barbier reaction of phenyl and alkyl N-(2-iodophenyl)-N-methylaminomethyl ketones with n-BuLi, which were easily prepared from N-methyl-2-iodoaniline and bromomethyl ketones.The treatment of the indolines with acid gave the corresponding indoles in quantitative yields.