1127405-08-6

Basic information

• Product Name: 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione
• Synonyms: 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione
• CAS NO: 1127405-08-6
• Molecular Weight: 298.136
• Mol File: 1127405-08-6.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione(1127405-08-6)
• EPA Substance Registry System: 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione(1127405-08-6)

Safety Data

• Hazardous Substances Data: 1127405-08-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 4654-39-1 4-bromophenethanol 
• 67-66-3 chloroform 
• 589-87-7 1,4-bromoiodobenzene 
• 4203-30-9 1-(4-bromo-phenyl)-2-diazo-ethanone 
• 80793-25-5 3-(4-bromophenyl)propanal 
• 201230-82-2 carbon monoxide 
• 68-12-2 N,N-dimethyl-formamide 
• 501358-04-9 1-(4-bromophenyl)-2-(methyl(phenyl)amino)ethan-1-one 
• 99-90-1 para-bromoacetophenone 
• 106-49-0 p-toluidine 
• 62-53-3 aniline 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 62558-60-5 1-(4-bromophenyl)-2-(phenylamino)ethanone 

Relevant articles and documents

Preparation method of alpha-carbonyl amide compound

The invention discloses a preparation method of an alpha-carbonyl amide compound. The method comprises the following steps: under the action of a catalyst, taking oxygen as an oxidant, and carrying out oxidative amidation reaction on an alpha-diazoketone compound shown in a chemical formula 2 and a cyclic secondary amine compound shown in a chemical formula 3 in an organic solvent to obtain the alpha-carbonyl amide compound shown in a chemical formula 1, wherein the formulas 1, 2 and 3 are also shown in the speification. According to the preparation method disclosed by the invention, the alpha-carbonyl amide compound is obtained by taking oxygen as the oxidizing agent and catalyzing alpha-diazoketone and cyclic secondary amine to be subjected to oxidative amidation reaction through cuprous iodide, the reaction condition is mild, the reaction time is short, and the byproduct of the reaction is only nitrogen, so that the method is an effective way for green and efficient preparation of the alpha-carbonyl amide compound.

Cu-Catalyzed aerobic oxidative cleavage of C(sp3)–C(sp3) bond: Synthesis of α-ketoamides

A novel synthesis of α-ketoamides from Cu-catalyzed aerobic oxidative C(sp3)–C(sp3) bond cleavage of hydrocinnamaldehydes has been developed. Readily available and environmentally benign oxygen is used as the oxidant. This reaction avoids the use of noble metal catalysts or specialized oxidants, and chemoselectively yields α-ketoamide. Moreover, based on various control experiments, a reasonable mechanism is proposed.

POP-Pd(ii) catalyzed easy and safe: In situ carbonylation towards the synthesis of α-ketoamides from secondary cyclic amines utilizing CHCl3 as a carbon monoxide surrogate

A novel complex catalyst, POP-palladium(ii), has been synthesized. The developed catalyst has been characterized by XRD, EDX, scanning electron microscopy (FE-SEM), HR-TEM, FTIR spectroscopy, UV-vis spectroscopy, TGA and BET isotherm analysis. The reactiv