501368-41-8

Basic information

• Product Name: 2-Pyrrolidinone, 1-(4-benzoylphenyl)-3-(trifluoromethyl)-
• CAS NO: 501368-41-8
• Molecular Formula: C18H14F3NO2
• Molecular Weight: 333.31
• Mol File: 501368-41-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 1-(4-benzoylphenyl)-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 1-(4-benzoylphenyl)-3-(trifluoromethyl)-(501368-41-8)
• EPA Substance Registry System: 2-Pyrrolidinone, 1-(4-benzoylphenyl)-3-(trifluoromethyl)-(501368-41-8)

Safety Data

• Hazardous Substances Data: 501368-41-8(Hazardous Substances Data)

Upstream product

• 174744-18-4 α-trifluoromethyl-γ-butyrolactone 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 501368-48-5 N-(4-benzoylphenyl)-4-hydroxy-2-trifluoromethylbutanamide 

Relevant articles and documents

N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers.

Based on the most stable conformation of ZD6169, a series of N-arylated derivatives of oxazolidindione (2), morpholin-3-one (3-5), piperidin-2-one (6), and pyrrolidin-2-one (7-13) was synthesized and evaluated for potassium channel opening activity. In the in-vitro assays, N-(4-benzoylphenyl)-piperidin-2-on (6) and N-(4-benzoylphenyl)-3,3-dimethyl-pyrrolidin-2-one (9) demonstrated potent and selective relaxant activity at the bladder detrusor muscle [IC50, bladder)=7.4 and 6.7 microM, respectively; IC50 ratio (portal vein/bladder)=41 and 51, respectively].