501419-08-5Relevant academic research and scientific papers
Enantioselective total synthesis of borrelidin
Duffey, Matthew O.,LeTiran, Arnaud,Morken, James P.
, p. 1458 - 1459 (2007/10/03)
The first total synthesis of the natural product borrelidin is described. The propionate fragment of the molecule was concisely synthesized through catalytic enantioselective reductive aldol reactions, a catalytic Negishi coupling, and a catalytic directed hydrogenation. The propionate segment was then fused to the vinyl iodide fragment through a catalytic Sonogashira coupling. Subsequent catalytic hydrostannylation and catalytic cyanation allowed access to the target structure. Copyright
